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KMID : 0359819940230020204
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 2 p.204 ~ p.214
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Role of Radiation Therapy in Treatment of Benign Meningiomas
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이정일
정희원/김봉수/정여섭/김인하/한대희
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Abstract
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Authors report five patients (four males and one female, aged 28-54 years) with intracranial meningioma in which 60Co-irradiation produced a beneficial effect. Radiation was delivered over periods from 39 to 51 days with a total dose of 5000 to
5500cGy.
Irradiation alone was performed in two patients including one recurrent case; irradiation followed by surgery in one, and postoperative irradiation for the residual tumor in two. Histopathological examination was done in four cases and none of
them
were
malignant or hemangiopericytic type. Two cases of highly vascular tumors showed marked shrinkage of the tumor after irradiation. Another highly vascular meningioma showed decrease of the tumor vascularity and degree of contrast enhancement in
magnetic
resonance image(MRI). One recurrent case developed a prominent cystic change suggesting development of tumor necrosis due to irradiation and the tumor growth has been arrested for one year after irradiation. In one patient with a cavernous sinus
meningioma, the tumor with progressive growth after incomplete resection showed a definite decrease in its size. With these observations, it is suggested that; 1) benign meningiomas may develop marked shrinkage, cystic change or decreased
vascularity in
response to irradiation; 2) there is a tendency that irradiation may be helpful for the operation on highly vascular meningiomas; 3) in patients with a high surgical risk, irradiation alone may be performed to obtain reduction of the tumor volume
or
arrest of growth; 4) preoperative irradiation may facilitate surgical removal of the tumor by reducing amount of intraoperative bleeding even in benign meningiomas; 5) as a sole treatment or a preoperative adjuvant therapy irradiation should be
considered in patients who are not favorable candidates for operation or radiosurgery.
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KEYWORD
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